Patrick Fickers
Univerity of Liège, Belgium
Title: Antibiotic from Bacillus, new compounds to solve an old problem
Biography
Biography: Patrick Fickers
Abstract
The worldwide emergence of multidrug-resistant pathogens is a serious medical concern nowadays. The need to discover new bioactive molecules active against these bacteria is crucial and is one of the main fields of research for modern microbiologists. Most natural antibiotics used in medicine are biosynthesized by Gram-positive bacteria. Recent advances in genomics and genome sequencing have shown that the potential of these organisms to produce molecules of pharmacological interest has been greatly underestimated. Full genome sequencing has revealed biosynthesis pathways for peptides manufactured by the conventional ribosomal assembly and NRPS metabolites (nonribosomal peptide synthetase). Here, we will report on the NRPS metabolite Mycosubtilin and the ribosomally synthesized peptide Amylolysin, both produced by Bacillus sp.
