Ravindra P V
Indian Veterinary Research Institute, India
Title: Anti-neoplastic effect of haemagglutinin-neuraminidase (HN) protein of the Newcastle disease virus on Rous sarcoma virus-induced tumors in chicken
Biography
Biography: Ravindra P V
Abstract
In the present study, the in-vivo antineoplastic effect of the NDV HN protein was investigated using a Rous sarcoma virus (RSV)-induced tumor model in chicken. Signs of tumor contraction, formation of scars at the injection site, a decrease in the mitotic, AgNOR, PCNA indices, increase in TUNEL positive nuclei and cells with a condensed nucleus compared to the control groups suggested that the NDV HN protein was capable of inducing tumor regression through the induction of apoptosis in RSV-induced tumors in chicken. The present study suggests that the NDV HN protein could be a potential candidate for the treatment of cancer(s) in the future.